Staff network from many government universities called recently on the Thai Higher Education Commission to solve their job insecurity, low salary and job and environmental condition stresses resulting from government occupational policy regarding education and occupation. The aim of this study is to investigate the causal relationship of occupational stress among male academic university employees in Thailand. The research conducted in this study was a cross-sectional study among 2,000 male academic employees who worked at Thai government universities in Thailand. The stratified random sampling method was used. Causal variables consisted of wages, family support, periods of duty and job and environmental condition. The effect variable consisted of stress. The results of this study found that job and environmental condition, which is one of the psychosocial dimensions of occupational health, had the most direct effect on stress (p<0.05) while variables such as family support and periods of duty were occupational stress at the low level. The most significant causal variable was job and environmental condition related to occupational stress among male academic university employees in Thailand. Some suggestions for the next research are that greater importance should be placed on psychosocial research in Thailand, especially qualitative method among male academic university employees to confirm these results, and that there should be comparisons between female and male academic university employees.