Home-based food businesses are trending among the new generation of food entrepreneurs, particularly during and after the COVID-19 pandemic. This review aims to provide a general scenario of home-based food businesses in Malaysia, possible contamination sources associated with home-based food and foodborne pathogens that can be linked to common food in Malaysia. Home -based food business is an integral part of food supply chain sells through local markets, online platforms, delivery services or direct pick up whereby food safety is a critical component to be taken care of. This review paper explores initiatives by Ministry of Health in order to create awareness and safety measures in different level of food business. This review also highlights current home-based food guidelines in Malaysia and the knowledge, practice, and attitude (KAP) linked to food operators in Malaysia. This paper also synthesizing current research associated with KAP food handlers and provides insights of future direction of improving food safety systems particularly for home-based food business.