PERTANIKA JOURNAL OF SOCIAL SCIENCES AND HUMANITIES

In Kelantan, the prevalence of Tuberculosis (TB) treatment success rate among TB/HIV co-infection is still below the success target of the World Health Organisation (WHO). Our objective was to assess the socio-demographic profile and determine the prevalence of TB treatment outcomes among TB/HIV co-infected patients in Kelantan. The cross-sectional study involved secondary data from the MyTB online system from January 2014 to December 2018, carried out at TB/Leprosy Sector, State Health Department of Kelantan. The data were analysed using SPSS version 25.0 and STATA version 14. The ethics approval was obtained from the UniSZA Human Research Ethics Committee (UHREC) and Medical Research Ethics Committee (MREC) of Ministry of Health (MOH). There were 6,313 TB cases in Kelantan. Of these, 703 (11.1%) cases were TB/HIV co-infection. However, 36 cases were excluded, and 667 cases were evaluated based on inclusion and exclusion criteria. The mean (SD) age was 38.7 (7.9) years, and the mean duration of TB treatment was 202.8 (131.27) days. The prevalence of successful treatment was 57.1%, with 19.8% cases were cured, and another 37.3% cases were completed treatment. While the unsuccessful were 42.9%, with 10.1% cases were defaulted, and 32.8% cases died. The successful outcomes were significantly associated with the educational level, the anatomy of TB location, smoking status, DOTS by health care providers, source of notification, the place of treatment and method of detection. This study provides the basic data of patient’s socio-demographic profiles, and the prevalence of TB treatment success in Kelantan is under international target by WHO of ≥ 90.0%.

• Abrha, H., Tsehayneh, B., Massa, D., Tesfay, A., & Kahsay, H. (2015). Survival experience and its predictors among TB/HIV co-infected patients in Southwest Ethiopia. Epidemiology (Sunnyvale), 5(3), 3-9. https://doi.org/10.4172/2161-1165.1000191

• Adejumo, O. A., Daniel, O. J., Otesanya, A. F., Adegbola, A. A., Femi-Adebayo, T., Bowale, A., Adesola, S., Kuku, O. O., Otemuyiwa, K. O., Oladega, S. N., Johnson, E. O., Falana, A. A., Dawodu, O., Owuna, H., Osoba, G., & Dacosta, A. (2017). Factors associated with TB/HIV co-infection among drug sensitive tuberculosis patients managed in a secondary health facility in Lagos, Nigeria. African Journal of Infectious Diseases, 11(2), 75-82. https://doi.org/10.21010/ajid.v11i2.10

• Ali, S. A., Mavundla, T. R., Fantu, R., & Awoke, T. (2016). Outcomes of TB treatment in HIV co-infected TB patients in Ethiopia: A cross-sectional analytic study. BMC Infectious Diseases, 16(1), Article 640. https://doi.org/10.1186/s12879-016-1967-3

• Ansa, G. A., Walley, J. D., Siddiqi, K., & Wei, X. (2012). Assessing the impact of TB/HIV services integration on TB treatment outcomes and their relevance in TB/HIV monitoring in Ghana. Infectious Diseases of Poverty, 1(1), 1-8. https://doi.org/10.1186/2049-9957-1-13

• Belayneh, M., Giday, K., & Lemma, H. (2015). Treatment outcome of Human Immunodeficiency Virus and Tuberculosis co-infected patients in public hospitals of eastern and southern zone of Tigray Region, Ethiopia. Brazilian Journal of Infectious Diseases, 19(1), 47-51. https://doi.org/10.1016/j.bjid.2014.09.002

• Duru, C. B., Uwakwe, K. A., Nnebue, C. C., Diwe, K. C., Merenu, I. A., Emerole, C. O., Iwu, C. A., & Duru, C. A. (2016). Tuberculosis treatment outcomes and determinants among patients treated in hospitals in Imo State, Nigeria. OALib, 03(06), 1-17. https://doi.org/10.4236/oalib.1102754

• Eyasu, E., Tadesse, B., & Tsedeke, W. (2014). Tuberculosis treatment outcomes among Tuberculosis/Human Immunodeficiency co-infected cases treated under directly observed treatment of short course in western Ethiopia. Journal of AIDS and HIV Research, 6(8), 164-171. https://doi.org/10.5897/jahr2014.0312

• Fekadu, G., Turi, E., Kasu, T., & Bekele, F. (2020). Impact of HIV status and predictors of successful treatment outcomes among Tuberculosis patients : A six-year retrospective cohort study. Annals of Medicine and Surgery, 60, 531-541. https://doi.org/10.1016/j.amsu.2020.11.032

• Fiseha, T., Gebru, T., Gutema, H., & Debela, Y. (2015). Tuberculosis treatment outcome among HIV co-infected patients at Mizan-Aman General Hospital, Southwest Ethiopia: A retrospective study fiseha. Bioengineering & Biomedical Science, 5(1), 1-4. https://doi.org/10.4172/2155-9538.1000139

• Hannah, H. A., Miramontes, R., & Gandhi, N. R. (2017). Sociodemographic and clinical risk factors associated with Tuberculosis mortality in the United States, 2009-2013. Public Health Reports, 132(3), 366-375. https://doi.org/10.1177/0033354917698117

• Ismail, I., & Bulgiba, A. (2013). Determinants of unsuccessful Tuberculosis treatment outcomes in Malaysian HIV-infected patients. Preventive Medicine, 57(SUPPL), S27-S30. https://doi.org/10.1016/j.ypmed.2012.12.023

• Jacobson, K. B., Moll, A. P., Friedland, G. H., & Shenoi, S. V. (2015). Successful Tuberculosis treatment outcomes among HIV/TB coinfected patients down-referred from a district hospital to primary health clinics in rural South Africa. PLoS ONE, 10(5), 1-11. https://doi.org/10.1371/journal.pone.0127024

• Jalal, T. M. T., Abdullah, S., Wahab, F. A., Dir, S., & Naing, N. N. (2017). Prevalence and factors associated with Tuberculosis treatment success among TB/ HIV co-infection in north-east Malaysia. Malaysian Journal of Medical Sciences, 24(6), 75-82. https://doi.org/10.21315/mjms2017.24.6.9

• Liew, S. M., Khoo, E. M., Ho, B. K., Lee, Y. K., Mimi, O., Fazlina, M. Y., Asmah, R., Lee, W. K., Harmy, M. Y., Chinna, K., & Jiloris, F. D. (2015). Tuberculosis in Malaysia: Predictors of treatment outcomes in a national registry. International Journal of Tuberculosis and Lung Disease, 19(7), 764-771. https://doi.org/10.5588/ijtld.14.0767

• Liu, Y., Zheng, Y., Chen, J., Shi, Y., Shan, L. Y., Wang, S., Wang, W. B., Shen, X., & Zhang, Y. (2018). Tuberculosis-associated mortality and its risk factors in a district of Shanghai, China: A retrospective cohort study. International Journal of Tuberculosis and Lung Disease, 22(6), 655-660. https://doi.org/10.5588/ijtld.17.0726

• Mekonnen, D., Derbie, A., & Desalegn, E. (2015). TB/HIV co-infections and associated factors among patients on directly observed treatment short course in Northeastern Ethiopia: A 4 years retrospective study. BMC Research Notes, 8(1), 1-6. https://doi.org/10.1186/s13104-015-1664-0

• Ministry of Health. (2015). Global AIDS response progress report Malaysia 2015. In Ministry of Health (Issue March).

• Ministry of Health Ethiopia. (2013). National TB/HIV sentinel surveillance one year report (July 2011 - June 2012). Ministry of Health Ethiopia.

• Ministry of Health Malaysia. (2012). Clinical practice guidelines: Management of Tuberculosis (3rd Ed.). Ministry of Health Malaysia.

• Ministry of Health Malaysia. (2016). Clinical practice guidelines: Management of drug-resistant Tuberculosis (1st Ed.). Ministry of Health Malaysia.

• Ofoegbu, O. S., & Odume, B. B. (2015). Tuberculosis patients at National Hospital Abuja Nigeria: A five year retrospective study. South African Family Practice, 57(1), 50-56. https://doi.org/10.1080/20786190.2014.995913

• Oshi, D. C., Oshi, S. N., Alobu, I., & Ukwaja, K. N. (2014). Profile, outcomes, and determinants of unsuccessful Tuberculosis treatment outcomes among HIV-infected Tuberculosis patients in a Nigerian State. Tuberculosis Research and Treatment, 2014, 1-8. https://doi.org/10.1155/2014/202983

• Ronaidi, N. M. N. N., Mohd, N. S., Mohammad, W. Z., Sharina, D., & Rosmawati, N. H. N (2011). Factors associated with unsuccessful treatment outcome of Pulmonary Tuberculosis in Kota Bharu, Kelantan. Malaysian Journal of Public Health Medicine, 11(1), 6-15.

• Sinshaw, Y., Alemu, S., Fekadu, A., & Gizachew, M. (2017). Successful TB treatment outcome and its associated factors among TB/HIV co-infected patients attending Gondar University Referral Hospital, Northwest Ethiopia: An institution based cross-sectional study. BMC Infectious Diseases, 17, 1-9. https://doi.org/10.1186/s12879-017-2238-7

• Tok, P. S. K., Liew, S. M., Wong, L. P., Razali, A., Loganathan, T., Chinna, K., Ismail, N., & Kadir, N. A. (2020). Determinants of unsuccessful treatment outcomes and mortality among Tuberculosis patients in Malaysia: A registry-based cohort study. PLoS ONE, 15(4), 1-14. https://doi.org/10.1371/journal.pone.0231986

• Tweya, H., Feldacker, C., Phiri, S., Ben-Smith, A., Fenner, L., Jahn, A., Kalulu, M., Weigel, R., Kamba, C., Banda, R., Egger, M., & Keiser, O. (2013). Comparison of treatment outcomes of new smear-positive Pulmonary Tuberculosis patients by HIV and antiretroviral status in a TB/HIV Clinic, Malawi. PLoS ONE, 8(2), Article e56248. https://doi.org/10.1371/journal.pone.0056248

• Warkari, P. D., Nakel, M. P., Mahajan, S. M., & Adchitre, S. A. (2017). Study of treatment outcome of Tuberculosis among HIV co-infected patients: A cross sectional study in Aurangabad City, Maharashtra. International Journal Of Community Medicine And Public Health, 4(12), 4466-4471. https://doi.org/10.18203/2394-6040.ijcmph20175163

• Wen, Yufeng, Zhang, Zhiping, Li, Xianxiang, Xia, Dan, Jun, M., Dong, Y., & Zhang, X. (2018). Treatment outcomes and factors affecting unsuccessful outcome among new Pulmonary smear positive and negative Tuberculosis patients in Anqing, China: A retrospective study. BMC Infectious Diseases, 18(104), 1-12. https://doi.org/https://doi.org/10.1186/s12879-018-3019-7

• WHO. (2006). The stop TB strategy. World Health Organization.

• WHO. (2008). A revised framework to address TB-HIV co-infection in the Western Pacific Region. World Health Organization.

• WHO. (2017). Global Tuberculosis report 2017. World Health Organization.

• WHO. (2018a). Global Tuberculosis report 2018. World Health Organization.

• WHO. (2018b). TB-HIV factsheet 2018. World Health Organization.

• WHO. (2019). Global Tuberculosis report 2019: Executive summary. World Health Organization.