e-ISSN 2231-8542
ISSN 1511-3701
S. Khozirah, A. Noor Rain, M.J. Siti Najila, Z. Imiyabir, L. Madani, C. Rohaya, M. Rosilawati, H. Nuziah, S.H. Goh and I. Zakiah
Pertanika Journal of Tropical Agricultural Science, Volume 19, Issue 1, January 2011
Keywords: Plasmodium falciparum, lactate dehydrogenase assay, Polyalthia insignis, Kopsia dasyrachis, Neouvaria acuminatissima, antimalarial
Published on:
The antiplasmodial activity of the crude extracts of thirty plant species collected from Sabah was evaluated using chloroquine-sensitive strain (D10) and chloroquine-resistant strain (Gombak A) of Plasmodium falciparum. Significant activities were observed for the bark extract of Polyalthia insignis (IC50 3.89 and 11.89 µg/ml against Gombak A and D10, respectively), the leaf extracts of Kopsia dasyrachis (4.62 µg/ml against Gombak A) and Litsea elliptibacea (IC50 8.88 µg/ml against Gombak A), as well as the leaf and bark extracts of Neouvaria acuminatissima (IC50 6.90-10.08 and 0.69 µg/ml against Gombak A and D10, respectively), and the bark extract of Polyalthia microtus (IC50 9.0 and 12.12 µg/ml against Gombak A and D10, respectively).
ISSN 1511-3701
e-ISSN 2231-8542