Rapid globalisation has translated to growth , but the resulting gains have not been reflected in qualitative welfare for most developing countries and thus, have precipitated inconclusive debates on the precise directional link between globalisation dimensions and changes in human welfare. Thus, this study examines the regional impact of the transmission channels of globalisation on human welfare in 16 Sub-Saharan African countries from 1980 to 2014. Using the panel fixed effect method, the findings reveal that trade openness enhanced human welfare development and the access of people to infrastructural facilities for the regions. FDI is found to be predominantly enhancing to human welfare in the Eastern and Southern Africa regions. Also, high labour migration and emigration of experts as a dimension of globalisation is found to worsen human welfare development and hinder basic infrastructural development in the regions, and lead to bad and ineffective governance. The study finds that the high level of social globalisation via labour inflow, access of people to telephone and Internet facilities enhanced the development of human welfare changes as evidenced in Southern Africa. Appropriate policy options are recommended to enhance human welfare development in the region.