PERTANIKA JOURNAL OF SCIENCE AND TECHNOLOGY

 

e-ISSN 2231-8526
ISSN 0128-7680

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Chemical Profile, Total Phenolic Content, DPPH Free Radical Scavenging and α-Glucosidase Inhibitory Activities of Cosmos Caudatus Kunth Leaves

Wan Nadilah Wan Ahmad, Khozirah Shaari, Alfi Khatib, Azizah Abdul Hamid and Muhajir Hamid

Pertanika Journal of Science & Technology, Volume 41, Issue 3, August 2018

Keywords: α-glucosidase inhibition, Cosmos caudatus, free radical scavenging activity, LC-MS/MS

Published on: 30 Aug 2018

Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos Caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents.

ISSN 0128-7680

e-ISSN 2231-8526

Article ID

JTAS-1327-2018

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